SN1 or SN2

polar protic solvent ke respect mein SN1 or strong Nu- ke respect mein SN2, toh SN1 hoga ya SN2?
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11 Replies
iTeachChem Helper
@Dexter
iTeachChem Helper
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stormycloud
stormycloud6d ago
SN1
Say_miracle_shadow
any reason?
Nimboi
Nimboi6d ago
might be because having a polar protic solvent interferes with the mechanism of Sn2 a lot
Nimboi
Nimboi6d ago
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Nimboi
Nimboi6d ago
nevermind, actually if there's H+ in the solution with nucleophile Nu, HNu might form instead of the thing we want considering that a single positive hydrogen ion is probably one of the best targets for a nucleophile to ever exist because of literally zero steric hinderance (speculation but you get the point)
stormycloud
stormycloud5d ago
KOH can be used for both SN1 and SN2, it depends on the substrate taken, here there is a possibility for a stable carbocation so I said SN1 Now if I were to take primary propanol or something, that time SN2 will take place Pls correct me if I am wrong
Say_miracle_shadow
so in secondary which will be preferred? but like if we take alc KOH elimination happens while with aq.KOH substitution takes place that means even it is aq. but still it gives substiution rxn.
iTeachChem
iTeachChem5d ago
James Ashenhurst
Master Organic Chemistry
Deciding SN1/SN2/E1/E2 - The Solvent
With a secondary alkyl halide and a poorly basic but strong nucleophile in a polar aprotic solvent, expect SN2. If the nucleophile is a strong base, expect E2, regardless of solvent.
iTeachChem
iTeachChem5d ago
Check out the other bits (substrate, overall comparison)

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