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FYI - Unusure if this answers the question, but ScyllaDB lists the following in their documentation:
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You can use up to 100:1 Disk/RAM ratio, with 30:1
Disk/RAM ratio as a good rule of thumb; for example, 30 TB of storage requires 1 TB of RAM.
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But this isn't inclusive of specific indeces set on node and vertice properties. So just wondering ....